Chili Con Queso Casserole

Prep: 10 min Cook: 40 min Serves: 8 Cuisine: Mexican

A cheesy, spicy casserole combining green chilies and tomatoes with a rich cheddar topping, perfect for casual gatherings and comfort food lovers seeking bold flavors.

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Ingredients

  • 2 cans (4 oz. each) chopped green chilies, drained
  • 2 large tomatoes, seeded and chopped
  • 2 cups shredded cheddar cheese
  • 1 cup Bisquick baking mix
  • 1/2 cup sour cream
  • 3 eggs

Instructions

  1. Grease a square 8 x 8 x 2 inch pan.
  2. Sprinkle drained chopped green chilies and chopped tomatoes evenly in the pan.
  3. In a bowl, beat the remaining ingredients with a wire whisk or hand beater until smooth.
  4. Pour the mixture over the chilies and tomatoes in the pan.
  5. Heat the oven to 375°F.
  6. Bake uncovered for 35 to 40 minutes or until a knife inserted in the center comes out clean.

Tips & Substitutions

For added flavor, consider incorporating cooked ground beef or turkey into the mixture. If you prefer a vegetarian option, substitute with black beans or corn. For a spicier version, use jalapeños or a hotter variety of green chilies. To enhance the cheese flavor, try mixing in pepper jack cheese with the cheddar. This recipe is also a great way to utilize leftovers from other Mexican recipes.

Serving Suggestions

Serve the casserole warm with tortilla chips or a side of fresh guacamole for a delightful contrast. It pairs beautifully with Jane's Sopapillas for a sweet finish. For a complete meal, consider serving it alongside a fresh salad or some Mexican-style rice. This dish is perfect for gatherings or family dinners.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place individual portions in the microwave for 1-2 minutes or until warmed through. Alternatively, reheat in the oven at 350°F for about 15-20 minutes, covered with foil to prevent drying out.

Nutrition & Diet Analysis (per serving)

Each serving of Chili Con Queso Casserole contains roughly 524 calories, with 15g protein, 81g carbohydrates, and 16g fat. It is an excellent source of calcium (43% of the Daily Value), protein (31% of the Daily Value), and vitamin A (30% of the Daily Value), and a good source of iron and potassium. Note that it is relatively high in sodium, at 580mg per serving (25% of the Daily Value).

524 kcal 26% DV
Protein Fat Carbs

Macronutrients

Protein 15.5g 31% DV
Total Fat 15.9g 20% DV
Carbs 81g 29% DV
Fiber 0.3g 1% DV
Sugar 10g 20% DV

Electrolytes

Sodium 579.8mg 25% DV
Potassium 571.7mg 12% DV
Cholesterol 194.6mg 65% DV

Vitamins & Minerals

Vitamin A 266.7mcg 30% DV
Vitamin C 10.1mg 11% DV
Vitamin D 0.5mcg 3% DV
Calcium 554.4mg 43% DV
Iron 2.4mg 14% DV
Diet fit Low-fat
Contains Milk Egg

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can prepare the casserole a day in advance. Simply assemble it in the pan, cover tightly with plastic wrap, and refrigerate. When ready to bake, remove the plastic wrap and follow the baking instructions. You may need to increase the baking time slightly if baking straight from the refrigerator.

Can I freeze the Chili Con Queso Casserole?

Absolutely! To freeze, let the casserole cool completely after baking, then wrap it tightly in plastic wrap and aluminum foil. It can be stored in the freezer for up to 3 months. To reheat, thaw in the refrigerator overnight and bake at 350°F until heated through.

What can I serve with Chili Con Queso Casserole?

This casserole pairs wonderfully with a variety of sides. Consider serving it with a fresh green salad, Mexican-style rice, or even some spiced black beans. For a fun appetizer, complement it with Fiesta Nibbles or a refreshing drink like horchata to balance the flavors.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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