Chicken And Biscuit Casserole

Prep: 15 min Cook: 35 min Serves: 6 Cuisine: American

Creamy chicken and vegetable casserole topped with cheesy biscuits offers hearty comfort and bold flavors, perfect for family dinners or casual gatherings.

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Ingredients

  • 8 slices bacon
  • 2 1/2 cups cooked chicken, diced
  • 10 oz. frozen mixed vegetables, cooked and drained
  • 1 cup chopped tomato
  • 1 1/2 cups shredded Cheddar cheese
  • 1 can cream of chicken soup
  • 3/4 cup milk (for soup)
  • 1 1/2 cups Bisquick
  • 2/3 cup milk (for Bisquick)

Instructions

  1. In a greased 8 x 12-inch baking pan, mix bacon, chicken, vegetables, tomatoes, and 2/3 cup grated cheese.
  2. Blend the cream of chicken soup with 3/4 cup milk and pour over the ingredients in the pan. Stir gently to combine.
  3. Cover and bake at 400°F for 15 minutes.
  4. Remove from oven and reduce temperature to 350°F.
  5. Prepare the biscuit topping by combining 1 1/2 cups Bisquick, 2/3 cup milk, and 1/2 can onions.
  6. Drop spoonfuls of the biscuit batter on top of the casserole to form biscuits.
  7. Bake uncovered for 15 to 20 minutes until the biscuits are golden brown.
  8. Sprinkle with remaining cheese and bake until melted.

Tips & Substitutions

For a richer flavor, consider using pancetta instead of bacon. If you want to lighten the dish, substitute low-fat cheese and use less cream of chicken soup. You can also add herbs like thyme or rosemary for an extra layer of flavor. If you don't have Bisquick, a homemade biscuit mix can be made using flour, baking powder, salt, and butter.

Serving Suggestions

Serve this hearty casserole with a side of mixed green salad or steamed broccoli for a balanced meal. It pairs beautifully with Charlotte'S Chicken & Rice for a larger gathering. A dollop of sour cream or a sprinkle of fresh herbs can add a nice finishing touch to the dish.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place in the oven at 350°F until warmed through, or microwave in individual portions. Adding a splash of milk before reheating can help maintain moisture in the biscuit topping.

Nutrition & Diet Analysis (per serving)

Each serving of Chicken And Biscuit Casserole contains roughly 731 calories, with 27g protein, 66g carbohydrates, and 40g fat. It is an excellent source of vitamin A (70% of the Daily Value), calcium (58% of the Daily Value), and protein (54% of the Daily Value), and a good source of potassium and dietary fiber. Note that it is relatively high in sodium, at 1330mg per serving (58% of the Daily Value).

731 kcal 37% DV
Protein Fat Carbs

Macronutrients

Protein 27g 54% DV
Total Fat 40.2g 52% DV
Carbs 65.9g 24% DV
Fiber 2.7g 10% DV
Sugar 33.9g 68% DV

Electrolytes

Sodium 1330.4mg 58% DV
Potassium 573.1mg 12% DV
Cholesterol 88.1mg 29% DV

Vitamins & Minerals

Vitamin A 627.2mcg 70% DV
Vitamin C 38.7mg 43% DV
Vitamin D 1.4mcg 7% DV
Calcium 754.7mg 58% DV
Iron 5.4mg 30% DV
Diet fit High-protein
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use leftover rotisserie chicken for this casserole?

Absolutely! Leftover rotisserie chicken is a perfect choice for this casserole, as it adds great flavor and saves time. Just make sure to dice it into bite-sized pieces to ensure even distribution throughout the dish.

What can I use instead of cream of chicken soup?

If you don't have cream of chicken soup, you can substitute it with homemade cream sauce or use a can of cream of mushroom soup for a different flavor. Mixing in some broth with a bit of flour can create a similar consistency and taste.

How do I make the biscuits fluffier?

To achieve fluffier biscuits, avoid overmixing the biscuit dough. Mix just until combined and let the batter rest for a few minutes before dropping spoonfuls onto the casserole. You can also add a touch more milk if the mixture seems too thick.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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