Barbecue Biscuit Casserole

Prep: 15 min Cook: 30 min Serves: 6 Cuisine: American

A hearty and flavorful casserole combining barbecue, beans, and biscuits topped with melted cheese, perfect for family dinners or casual gatherings with smoky, sweet, and savory notes.

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Ingredients

  • 1 lb ground chuck
  • 1 medium onion, chopped
  • 1 (16 oz) can pork and beans
  • 2 Tbsp brown sugar
  • 1 tsp salt
  • 3/4 cup barbecue sauce
  • 1 capful liquid smoke
  • 10 Pillsbury buttermilk biscuits
  • 1 cup shredded mild Cheddar cheese

Instructions

  1. Preheat oven to 375°F.
  2. Brown ground chuck and chopped onion in a skillet.
  3. Drain excess fat from the beef mixture.
  4. Stir in pork and beans, brown sugar, salt, barbecue sauce, and liquid smoke. Cook until bubbly.
  5. Pour the mixture into a 2-quart casserole dish and bake for 15 minutes.
  6. Cut each biscuit into halves to make 20 pieces.
  7. Remove casserole from oven and place biscuit halves, cut side down, on top of the casserole.
  8. Sprinkle shredded Cheddar cheese over the biscuits.
  9. Bake for an additional 15 minutes until biscuits are golden and cheese is melted.

Tips & Substitutions

For a twist, consider adding chopped bell peppers or jalapeños to the beef mixture for extra flavor. If you don't have liquid smoke, you can substitute with smoked paprika for a similar taste. Additionally, using turkey or chicken instead of ground chuck can lighten the dish. Pair with a side salad for a refreshing contrast.

Serving Suggestions

Serve the casserole hot, garnished with sliced green onions or a dollop of sour cream for added creaminess. It pairs wonderfully with a crisp coleslaw or some cornbread for a complete meal. For a fun twist, serve alongside Water Chestnuts Appetizers for a delightful spread.

Storage & Reheating

Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, place the casserole in the oven at 350°F until warmed through, about 20 minutes. Alternatively, microwave individual portions on medium power until hot, making sure to cover to retain moisture.

Nutrition & Diet Analysis (per serving)

Each serving of Barbecue Biscuit Casserole contains roughly 840 calories, with 31g protein, 110g carbohydrates, and 32g fat. It is an excellent source of protein (63% of the Daily Value) and calcium (20% of the Daily Value), and a good source of iron and potassium. Note that it is relatively high in sodium, at 2436mg per serving (106% of the Daily Value).

840 kcal 42% DV
Protein Fat Carbs

Macronutrients

Protein 31.5g 63% DV
Total Fat 31.5g 40% DV
Carbs 109.7g 40% DV
Fiber 2g 7% DV
Sugar 102.4g 100% DV

Electrolytes

Sodium 2436.3mg 100% DV
Potassium 813.6mg 17% DV
Cholesterol 108.8mg 36% DV

Vitamins & Minerals

Vitamin A 76.5mcg 8% DV
Vitamin C 0.4mg
Vitamin D 1.4mcg 7% DV
Calcium 263.3mg 20% DV
Iron 3.4mg 19% DV
Diet fit High-protein
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can prepare the beef and bean mixture in advance and assemble the casserole up to the point of baking. Cover and refrigerate overnight. When ready to bake, add the biscuit halves and cheese, then bake as directed, adding a few extra minutes if baking from cold.

What can I substitute for the barbecue sauce?

If you don't have barbecue sauce on hand, you can use a mix of ketchup, vinegar, and a touch of Worcestershire sauce to mimic the flavors. Additionally, homemade barbecue sauce can be made by combining tomato sauce, honey, and spices for a personalized touch.

Is this casserole suitable for freezing?

Yes, this casserole can be frozen before baking. Assemble the dish, cover it tightly with plastic wrap and aluminum foil, and freeze for up to 3 months. When ready to enjoy, thaw in the refrigerator overnight and bake as instructed, adding a few extra minutes for the biscuit topping.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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