Favorite Chicken Casserole

Prep: 20 min Cook: 90 min Serves: 6 Cuisine: American

A comforting chicken casserole featuring tender chicken breasts topped with a creamy blend of sour cream, cream of chicken or mushroom soup, and savory onion soup mix. Optional chow mein noodles add a crunchy texture, making it perfect for family dinners or casual gatherings.

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Ingredients

  • 8 boneless chicken breasts
  • 1 (8 oz.) carton sour cream
  • 1 can cream of chicken soup
  • 1 can cream of mushroom soup
  • 1 package dry Lipton onion soup mix

Instructions

  1. Place chicken breasts in a casserole dish.
  2. Mix sour cream, cream of chicken or mushroom soup, and onion soup mix together.
  3. Spread the mixture evenly over the chicken.
  4. Add chow mein noodles on top if desired.
  5. Bake at 325°F for 1 1/2 hours.

Tips & Substitutions

For a lighter version, consider using low-fat sour cream and substituting one of the cream soups with a homemade version. You can also add vegetables like broccoli or carrots for extra nutrition. If you prefer added crunch, top with crispy fried onions instead of chow mein noodles. Be sure to season the chicken breasts with salt and pepper before layering for enhanced flavor.

Serving Suggestions

This chicken casserole pairs beautifully with a side salad or steamed vegetables for a complete meal. Consider serving it alongside garlic bread or rice to soak up the creamy sauce. For a comforting twist, serve with a bowl of Broccoli Cheese Soup With Noodles for a hearty dinner experience.

Storage & Reheating

Store any leftover chicken casserole in an airtight container in the refrigerator for up to three days. To reheat, cover with foil and warm in the oven at 325°F for about 20-25 minutes, or until heated through. You can also microwave individual portions for 2-3 minutes, checking for doneness.

Nutrition & Diet Analysis (per serving)

Each serving of Favorite Chicken Casserole contains roughly 394 calories, with 20g protein, 56g carbohydrates, and 10g fat. It is an excellent source of protein (39% of the Daily Value), and a good source of calcium and vitamin A. Note that it is relatively high in sodium, at 752mg per serving (33% of the Daily Value).

394 kcal 20% DV
Protein Fat Carbs

Macronutrients

Protein 19.7g 39% DV
Total Fat 9.8g 13% DV
Carbs 55.7g 20% DV
Fiber 0.4g 2% DV
Sugar 0.7g 1% DV

Electrolytes

Sodium 752mg 33% DV
Potassium 373.2mg 8% DV
Cholesterol 61.7mg 21% DV

Vitamins & Minerals

Vitamin A 133.6mcg 15% DV
Vitamin C 0.4mg
Vitamin D 0.3mcg 1% DV
Calcium 197mg 15% DV
Iron 1.8mg 10% DV
Diet fit Under 400 cal Low-fat
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use frozen chicken breasts for this recipe?

Yes, you can use frozen chicken breasts, but it's best to thaw them first for even cooking. If using frozen, increase the baking time to ensure the chicken is cooked through, checking that the internal temperature reaches 165°F.

What can I substitute for sour cream?

If you don't have sour cream, Greek yogurt is a great substitute that adds a similar tang and creaminess. Alternatively, you can use a mixture of cream cheese and a splash of milk to achieve a comparable consistency.

How can I make this dish spicier?

To add heat, consider mixing in diced jalapeños or a dash of hot sauce into the sour cream mixture. You can also sprinkle red pepper flakes on top before baking for an extra kick.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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