Granny'S Chicken Casserole

Prep: 15 min Cook: 50 min Serves: 6 Cuisine: American

Granny's Chicken Casserole is a comforting baked dish featuring tender chicken breasts in a creamy sauce, complemented by savory stuffing. Perfect for family dinners, it combines rich flavors and hearty textures that appeal to all ages, offering a warm, satisfying meal with a classic homemade feel.

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Ingredients

  • 4 chicken breasts, cooked and deboned
  • 2 cans cream of chicken soup
  • 1 cup milk
  • 1 cup broth
  • 1 package corn bread stuffing mix

Instructions

  1. Place cooked and deboned chicken breasts in a casserole dish.
  2. Mix the cream of chicken soup with 1 cup of milk and pour over the chicken.
  3. Mix the stuffing mix with 1/2 cup melted butter and the broth from the cooked chicken.
  4. Spread the stuffing mixture over the chicken and soup layer.
  5. Bake at 350°F (175°C) for 45 to 50 minutes until bubbly and heated through.

Tips & Substitutions

For a creamier texture, consider adding a cup of sour cream or Greek yogurt to the soup mixture. If you want to enhance the flavor, you can mix in some sautéed onions or garlic. Feel free to substitute the cornbread stuffing mix with a traditional bread stuffing or even a gluten-free option if needed. Adjust the broth amount based on how moist you like your casserole.

Serving Suggestions

This hearty casserole pairs beautifully with a fresh green salad or steamed vegetables for a complete meal. You might also serve it alongside baked potatoes or rice for added bulk. For a cozy family dinner, try serving it with warm bread rolls. It's a comforting option that can satisfy even the pickiest eaters.

Storage & Reheating

Store leftovers in an airtight container in the refrigerator for up to three days. To reheat, place the casserole in the oven at 350°F (175°C) for about 20-30 minutes, covered with foil to prevent drying out. You can also microwave individual portions for a quick meal, but the oven method will keep it more flavorful.

Nutrition & Diet Analysis (per serving)

Each serving of Granny'S Chicken Casserole contains roughly 516 calories, with 33g protein, 41g carbohydrates, and 24g fat. It is an excellent source of protein (66% of the Daily Value) and iron (25% of the Daily Value), and a good source of vitamin A and calcium. Note that it is relatively high in sodium, at 973mg per serving (42% of the Daily Value).

516 kcal 26% DV
Protein Fat Carbs

Macronutrients

Protein 33g 66% DV
Total Fat 23.5g 30% DV
Carbs 41.3g 15% DV
Fiber 1.1g 4% DV
Sugar 19g 38% DV

Electrolytes

Sodium 973.3mg 42% DV
Potassium 455.9mg 10% DV
Cholesterol 93.1mg 31% DV

Vitamins & Minerals

Vitamin A 166.7mcg 19% DV
Vitamin C 6.7mg 7% DV
Vitamin D 1.2mcg 6% DV
Calcium 197.9mg 15% DV
Iron 4.4mg 25% DV
Diet fit High-protein
Contains Milk Wheat/Gluten

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use leftover chicken for this recipe?

Absolutely! Using leftover rotisserie chicken or any cooked chicken will save time and add great flavor. Just be sure to shred or chop it into bite-sized pieces for even distribution in the casserole.

Can I prepare this dish ahead of time?

Yes, you can assemble the casserole ahead of time and store it in the refrigerator for up to 24 hours before baking. Just add an additional 10-15 minutes to the baking time if baking straight from the fridge.

What can I use instead of cream of chicken soup?

If you're looking for a substitute, you can make a homemade version using a roux of flour and butter, combined with chicken broth and milk. Alternatively, use cream of mushroom or a dairy-free cream soup for a different flavor profile.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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