Meat Loaf Manhattan

Prep: 15 min Cook: 40 min Serves: 6 Cuisine: American

A hearty meat loaf infused with garlic, onion, and smoky barbecue sauce, perfect for comfort food lovers and family dinners with bold flavors.

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Ingredients

  • 2 lb. lean beef
  • 2 eggs
  • 3 cloves garlic
  • 1 large sweet onion
  • 1/2 cup whole milk
  • 1 (10 to 12 oz.) bottle barbecue sauce
  • 1 Tbsp. salt
  • 1 Tbsp. cayenne pepper
  • 1 1/2 cups oats

Instructions

  1. Preheat oven to 350°F.
  2. Chop onion and garlic to desired size and mix with all ingredients except oats and barbecue sauce using your hands.
  3. Let the meat rest from the refrigerator before starting.
  4. Add 1/2 of the barbecue sauce and oats to the mixture and continue to mix well.
  5. Form the mixture into a loaf shape and place it in a baking dish.
  6. Spread the remaining barbecue sauce on top and sides of the loaf.
  7. Bake for about 40 minutes.

Tips & Substitutions

For added moisture, consider incorporating grated zucchini or shredded carrots into the meat mixture. If you prefer a milder flavor, you can reduce the cayenne pepper or replace it with smoked paprika for a different depth. Using rolled oats is key for texture, but quick oats can be substituted if needed. Ensure the meat loaf rests before slicing to maintain juiciness.

Serving Suggestions

Serve slices of this meat loaf with a side of creamy mashed potatoes and steamed green beans for a classic comfort meal. A fresh garden salad pairs well to balance the richness. For a twist, try it on a toasted bun with lettuce and tomato, creating a delicious meat loaf sandwich. This dish is perfect for family dinners or gatherings.

Storage & Reheating

To store leftovers, wrap the meat loaf tightly in plastic wrap or aluminum foil and refrigerate for up to 3 days. For longer storage, freeze slices in an airtight container for up to 3 months. Reheat in the oven at 300°F until warmed through or in the microwave for a quick meal. Avoid reheating multiple times to maintain quality.

Nutrition & Diet Analysis (per serving)

Each serving of Meat Loaf Manhattan contains roughly 262 calories, with 6g protein, 46g carbohydrates, and 6g fat. It is a good source of iron (15% of the Daily Value), protein (12% of the Daily Value), and calcium (10% of the Daily Value). Note that it is relatively high in sodium, at 1375mg per serving (60% of the Daily Value).

262 kcal 13% DV
Protein Fat Carbs

Macronutrients

Protein 6.2g 12% DV
Total Fat 6.4g 8% DV
Carbs 46g 17% DV
Fiber 2.6g 9% DV
Sugar 11.9g 24% DV

Electrolytes

Sodium 1375.2mg 60% DV
Potassium 288.2mg 6% DV
Cholesterol 54.3mg 18% DV

Vitamins & Minerals

Vitamin A 77.2mcg 9% DV
Vitamin C 4.8mg 5% DV
Vitamin D 0.3mcg 1% DV
Calcium 130.5mg 10% DV
Iron 2.6mg 15% DV
Diet fit Under 400 cal Low-fat
Contains Milk Egg

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use ground turkey instead of beef?

Yes, ground turkey can be used as a healthier alternative. However, be aware that it tends to be drier than beef, so you may want to add a bit more milk or a tablespoon of olive oil to keep it moist. Seasoning may also need to be adjusted to enhance flavor.

What can I substitute for barbecue sauce?

If you don’t have barbecue sauce on hand, you can mix ketchup with Worcestershire sauce and a bit of brown sugar for a homemade version. Alternatively, a mix of tomato sauce with spices like garlic powder and paprika can create a tangy glaze. Adjust the sweetness based on your preference.

How do I know when the meat loaf is done?

The best way to check if the meat loaf is done is to use a meat thermometer. It should read 160°F in the center. Additionally, the juices should run clear when cut. Allowing it to rest for about 10 minutes after baking will make it easier to slice and help retain moisture.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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