Oven-Barbecued Beef Brisket

Prep: 15 min Cook: 240 min Serves: 8 Cuisine: American

Oven-Barbecued Beef Brisket offers tender, flavorful slices with a smoky, savory taste. The slow roasting process ensures juicy meat infused with Worcestershire sauce, liquid smoke, and melted margarine. Perfect for gatherings or a hearty family dinner, it delivers comforting Southern-style barbecue with minimal effort.

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Ingredients

  • 5 lb. beef brisket
  • 1 bottle Worcestershire sauce
  • 1 bottle liquid smoke
  • 1 stick margarine

Instructions

  1. Trim the brisket well.
  2. Place the brisket in a large deep roasting pan.
  3. Heat the Worcestershire sauce, liquid smoke, and melted margarine, then pour over the brisket.
  4. Cover the pan tightly with heavy-duty aluminum foil.
  5. Cook in the oven at 250°F for 1 hour per pound, approximately 5 hours for a 5 lb. brisket. Alternatively, cook at 425°F for 30 minutes, then reduce the temperature to 325°F and cook for 30 to 40 minutes per pound.
  6. The meat is done when a fork inserts easily.
  7. Cool for 30 minutes, then cut into thin slices with an electric knife.

Tips & Substitutions

For enhanced flavor, marinate the brisket overnight in the Worcestershire sauce and liquid smoke mixture. If you prefer a slightly sweet taste, consider adding brown sugar or honey to the marinade. If you don't have liquid smoke, smoked paprika can be a good substitute. Use a meat thermometer to ensure perfect doneness; aim for an internal temperature of around 190°F for optimal tenderness.

Serving Suggestions

Serve the brisket with classic sides like coleslaw or baked beans for a hearty meal. It pairs beautifully with mashed potatoes or roasted vegetables. Consider slicing the brisket thinly for sandwiches, or serving it alongside the savory flavors of Beef-Barley Vegetable Soup for a comforting dinner option.

Storage & Reheating

Store leftover brisket in an airtight container in the refrigerator for up to 4 days. To reheat, wrap the slices in foil and warm them in a low oven (around 300°F) until heated through, which helps retain moisture. For longer storage, freeze the brisket wrapped tightly in plastic wrap and foil for up to 3 months.

Nutrition & Diet Analysis (per serving)

Each serving of Oven-Barbecued Beef Brisket contains roughly 392 calories, with 9g protein, 2g carbohydrates, and 39g fat. It is a good source of protein (18% of the Daily Value).

392 kcal 20% DV
Protein Fat Carbs

Macronutrients

Protein 9g 18% DV
Total Fat 39.4g 50% DV
Carbs 1.7g 1% DV
Fiber 0g
Sugar 0.8g 2% DV

Electrolytes

Sodium 418.6mg 18% DV
Potassium 218.4mg 5% DV
Cholesterol 29.3mg 10% DV

Vitamins & Minerals

Vitamin A 2.1mcg
Vitamin C 1mg 1% DV
Vitamin D 0mcg
Calcium 15mg 1% DV
Iron 1.3mg 7% DV
Diet fit Keto-friendly Under 400 cal

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use a different cut of meat for this recipe?

While brisket is ideal for this recipe due to its fat content and tenderness when cooked low and slow, you can substitute with other cuts like chuck roast. However, cooking times may vary, and you might need to adjust the cooking duration to ensure tenderness.

What can I do if my brisket is tough after cooking?

If the brisket turns out tough, it likely needs more cooking time. Try returning it to the oven and cooking it longer at a low temperature. Adding some moisture, like broth or additional marinade, can also help tenderize it during reheating.

How can I enhance the flavor of the brisket?

To elevate the flavor, consider adding spices like garlic powder, onion powder, or smoked paprika to the marinade. You can also experiment with different barbecue sauces after cooking for a unique taste. For a more complex flavor profile, try a rub with brown sugar and chili powder.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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