Poppy Seed Southern Chicken Casserole

Prep: 15 min Cook: 30 min Cuisine: American

A creamy, comforting chicken casserole with a crunchy cracker topping, perfect for family dinners and gatherings, offering rich flavors and a satisfying texture.

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Ingredients

  • 6 cups cooked chicken
  • 1 can cream of mushroom soup
  • 16 oz. sour cream
  • 1/2 lb. butter or margarine, softened
  • 3 cups Ritz crackers, crumbled

Instructions

  1. Arrange cooked chicken in a 9 x 13-inch baking dish.
  2. Blend the cream of mushroom soup and sour cream together.
  3. Pour the soup mixture over the chicken in the dish.
  4. Combine the softened butter or margarine with crumbled Ritz crackers and sprinkle on top of the casserole.
  5. Bake at 350°F (175°C) for 30 minutes or until hot and bubbly.

Tips & Substitutions

For added flavor, consider using shredded rotisserie chicken instead of cooked chicken. You can also substitute the cream of mushroom soup with cream of chicken soup for a different taste. If you prefer a bit of crunch, try adding some sautéed onions or bell peppers to the chicken layer. This dish is a great way to use up leftover chicken recipes and can be easily doubled for larger gatherings.

Serving Suggestions

This Poppy Seed Southern Chicken Casserole pairs beautifully with a fresh garden salad or steamed vegetables for a balanced meal. You can also serve it with cornbread or garlic bread to soak up the creamy sauce. For a comforting side, consider pairing it with mashed potatoes or a light pasta dish. It's perfect for family dinners or potlucks.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, cover the casserole with foil and bake in a 350°F (175°C) oven for about 20-25 minutes, or until heated through. You can also microwave individual portions, but be sure to cover them to prevent drying out.

Nutrition & Diet Analysis (per serving)

Each serving of Poppy Seed Southern Chicken Casserole contains roughly 1355 calories, with 25g protein, 120g carbohydrates, and 86g fat. It is an excellent source of protein (50% of the Daily Value), calcium (48% of the Daily Value), and vitamin A (32% of the Daily Value), and a good source of potassium. Note that it is relatively high in sodium, at 1143mg per serving (50% of the Daily Value).

1355 kcal 68% DV
Protein Fat Carbs

Macronutrients

Protein 25g 50% DV
Total Fat 86.5g 100% DV
Carbs 119.9g 44% DV
Fiber 2.6g 9% DV
Sugar 3.8g 8% DV

Electrolytes

Sodium 1143.1mg 50% DV
Potassium 670.9mg 14% DV
Cholesterol 224.3mg 75% DV

Vitamins & Minerals

Vitamin A 288mcg 32% DV
Vitamin C 0.5mg 1% DV
Vitamin D 0mcg
Calcium 624.2mg 48% DV
Iron 5.1mg 28% DV
Diet fit High-protein
Contains Milk Wheat/Gluten

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can prepare the casserole a day in advance. Just assemble it in the baking dish, cover it with plastic wrap, and refrigerate. When you're ready to bake, remove the wrap and add a few extra minutes to the baking time to ensure it's heated through.

Can I freeze this casserole?

Absolutely! You can freeze the assembled casserole before baking. Just cover it tightly with aluminum foil or plastic wrap. When ready to bake, thaw it in the refrigerator overnight, then bake as directed. For best results, consume within 2-3 months.

What can I substitute for sour cream?

If you need a substitute for sour cream, Greek yogurt works well as a healthier option with a similar tangy flavor. You could also use crème fraîche or even cottage cheese for a different texture while maintaining creaminess in the casserole.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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