Cheeseburger Casserole

Prep: 10 min Cook: 20 min Serves: 4 Cuisine: American

A hearty, cheesy casserole combining savory ground beef, tangy barbecue sauce, and melty cheese, topped with biscuits for a comforting family favorite. Perfect for casual weeknights and easy to customize with your favorite toppings or spices, this dish is a crowd-pleaser with bold flavors.

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Ingredients

  • 1 lb ground chuck
  • 1 medium onion, chopped
  • 1 cup grated cheese
  • 1 cup barbecue sauce or ketchup
  • 1 (8 oz) can tomato sauce
  • oregano to taste
  • Worcestershire sauce to taste

Instructions

  1. Brown ground chuck and chopped onion in a frying pan.
  2. Add Worcestershire sauce, tomato sauce, and barbecue sauce to the pan.
  3. Stir well and sprinkle oregano over the mixture.
  4. Heat thoroughly until hot.
  5. Pour the mixture into a casserole dish.
  6. Sprinkle grated cheese over the mixture and top with quartered biscuits.
  7. Bake at 350°F for 15 to 20 minutes, or until biscuits are browned.

Tips & Substitutions

For a lighter version, consider substituting ground turkey for the ground chuck, and opt for low-fat cheese. If you don't have biscuits, crescent roll dough can be a fun alternative. To elevate the flavor, try adding diced bell peppers or mushrooms when browning the meat. Adjust the barbecue sauce to your taste; a smoky variety can add depth.

Serving Suggestions

This cheeseburger casserole pairs beautifully with a simple side salad or steamed vegetables for a balanced meal. For a fun twist, serve with pickles or a dollop of sour cream. You can also explore pairing this dish with American recipes like Country Mashed Potatoes for a comforting feast.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place in the microwave for a few minutes or cover with foil and bake at 350°F until warmed through. If the biscuits become too soft, a quick broil at the end can help crisp them back up.

Nutrition & Diet Analysis (per serving)

Each serving of Cheeseburger Casserole contains roughly 614 calories, with 33g protein, 100g carbohydrates, and 20g fat. It is an excellent source of iron (222% of the Daily Value), dietary fiber (177% of the Daily Value), and calcium (149% of the Daily Value), and a good source of vitamin A. Note that it is relatively high in sodium, at 784mg per serving (34% of the Daily Value).

614 kcal 31% DV
Protein Fat Carbs

Macronutrients

Protein 33.2g 66% DV
Total Fat 19.8g 25% DV
Carbs 100.3g 36% DV
Fiber 49.5g 100% DV
Sugar 16.4g 33% DV

Electrolytes

Sodium 784.2mg 34% DV
Potassium 1882.8mg 40% DV
Cholesterol 68.4mg 23% DV

Vitamins & Minerals

Vitamin A 122.8mcg 14% DV
Vitamin C 3.4mg 4% DV
Vitamin D 0.2mcg 1% DV
Calcium 1938.2mg 100% DV
Iron 40mg 100% DV
Diet fit High-protein High-fiber Low-fat
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Absolutely! You can prepare the casserole up to the baking step, cover it tightly, and refrigerate for up to 24 hours. When you're ready to bake, just add a few extra minutes to the cooking time as it will be cold from the fridge.

What can I substitute for barbecue sauce?

If you don't have barbecue sauce on hand, ketchup mixed with a teaspoon of mustard and a splash of vinegar can create a similar tangy flavor. Alternatively, a homemade sauce with brown sugar, vinegar, and spices can work well too.

Can I make this recipe vegetarian?

Yes, for a vegetarian version, substitute the ground chuck with a plant-based meat alternative, like lentils or crumbled tofu. You can also explore using vegetables like zucchini or mushrooms for added texture and flavor, making it a delicious option for vegetarian recipes.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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