Mexi-Chili Casserole

Prep: 10 min Cook: 25 min Serves: 6 Cuisine: Mexican

A flavorful Mexican-inspired casserole layered with chili, enchilada sauce, cheese, and crunchy chips, perfect for comforting family dinners or casual gatherings with bold, spicy flavors.

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Ingredients

  • 16 oz. pkg. chips
  • 2 c. sharp Cheddar cheese, grated
  • 2 (15 oz.) cans chili with beans
  • 2 (15 oz.) cans enchilada sauce (1 hot, 1 mild)
  • 8 oz. can tomato sauce
  • 1 medium onion, chopped
  • 1 lb. ground beef

Instructions

  1. Set aside 1 cup of chips and 1/2 cup of cheese for topping.
  2. Combine the chili with beans, enchilada sauces, tomato sauce, chopped onion, and cooked ground beef in a 1 1/2-quart casserole dish.
  3. Bake at 375°F for 20 minutes or until thoroughly heated.
  4. Sprinkle the top with the remaining chips and some of the grated cheese.
  5. Bake for an additional 5 minutes until cheese is melted and bubbly.
  6. Serve hot with sour cream.

Tips & Substitutions

For a vegetarian version, substitute the ground beef with black beans or lentils. You can also use Monterey Jack cheese instead of sharp Cheddar for a milder flavor. If you prefer more spice, add jalapeños or chili powder to the mix. This casserole can be customized with additional vegetables like bell peppers or corn, making it versatile for your taste.

Serving Suggestions

Serve this Mexi-Chili Casserole with a dollop of sour cream on top, and a side of Fiesta Rice for a complete meal. It pairs great with a fresh salad or some guacamole for added freshness. For a fun twist, consider serving it alongside Taco Bites for a festive gathering.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place in an oven-safe dish and cover with foil to prevent drying out, warming at 350°F until heated through. Alternatively, you can microwave individual portions for a quick meal.

Nutrition & Diet Analysis (per serving)

Each serving of Mexi-Chili Casserole contains roughly 901 calories, with 38g protein, 70g carbohydrates, and 54g fat. It is an excellent source of protein (77% of the Daily Value), calcium (50% of the Daily Value), and iron (48% of the Daily Value), and a good source of vitamin C. Note that it is relatively high in sodium, at 2255mg per serving (98% of the Daily Value).

901 kcal 45% DV
Protein Fat Carbs

Macronutrients

Protein 38.3g 77% DV
Total Fat 54.1g 69% DV
Carbs 69.8g 25% DV
Fiber 8.3g 30% DV
Sugar 18.9g 38% DV

Electrolytes

Sodium 2254.7mg 98% DV
Potassium 1180.8mg 25% DV
Cholesterol 125.8mg 42% DV

Vitamins & Minerals

Vitamin A 355.2mcg 39% DV
Vitamin C 9.4mg 10% DV
Vitamin D 0.6mcg 3% DV
Calcium 655.5mg 50% DV
Iron 8.7mg 48% DV
Diet fit High-protein High-fiber
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I prepare the casserole in advance?

Yes, you can assemble the casserole ahead of time and refrigerate it for up to 24 hours before baking. Just add a few extra minutes to the baking time if it’s coming straight from the fridge. This makes it a convenient option for busy weeknights or entertaining.

What type of chips work best for this recipe?

Corn tortilla chips are ideal as they hold up well against the casserole's moisture. You can also use tortilla strips for a crunchier texture. If you prefer a healthier alternative, consider baked chips or even nacho-flavored chips for an extra kick.

Can I freeze the Mexi-Chili Casserole?

Yes, this casserole freezes well. Allow it to cool completely, then wrap it tightly in plastic wrap and foil before freezing. It can be frozen for up to 3 months. To reheat, thaw in the refrigerator overnight and bake until hot throughout.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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