25 Pound Lasagna

Prep: 30 min Cook: 60 min Serves: 12 Cuisine: Italian

A hearty, cheesy lasagna layered with savory meats and rich tomato sauce, perfect for family dinners and gatherings craving comfort food with bold flavors.

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Ingredients

  • 1 lb. hamburger
  • 3 hot sausages
  • 1/2 lb. pepperoni
  • 1 can tomato sauce
  • 1 can tomato paste
  • 1 1/2 boxes lasagna
  • 1 Tbsp. Italian seasonings
  • 1 Tbsp. seasoned salt
  • 1 tsp. hot crushed peppers
  • 1 tsp. garlic powder
  • 1 tsp. onion powder
  • 2 (48 oz.) jars spaghetti sauce
  • 1/2 cup sugar
  • 4 lb. sliced Mozzarella cheese
  • 2 lb. shredded pizza cheese
  • 1 Tbsp. olive oil

Instructions

  1. Boil water in a large pan for cooking the lasagna noodles.
  2. Fry the hamburger until browned, then drain the grease.
  3. Fry the sausages until cooked through.
  4. Fry the pepperoni slices in olive oil until slightly crispy.
  5. Slice the cooked sausages.
  6. Mix the cooked meats together in a large bowl.
  7. Add tomato sauce, tomato paste, Italian seasonings, seasoned salt, hot crushed peppers, garlic powder, onion powder, and sugar to the meat mixture.
  8. Mix all ingredients well to combine.

Tips & Substitutions

For a richer flavor, consider adding sautéed onions and bell peppers to the meat mixture. If you want a lighter version, substitute ground turkey for the hamburger. Be sure to cook the noodles al dente, as they will continue to cook while baking. You can also try adding layers of spinach or mushrooms for extra vegetables. For variations, browse more Italian recipes.

Serving Suggestions

Serve this hearty lasagna with a side of garlic bread and a fresh green salad for a complete meal. A light vinaigrette pairs perfectly with the richness of the lasagna. For an Italian twist, consider serving with a glass of Chianti. This dish also pairs beautifully with Easy Pork Parmigiana, making it a great option for family gatherings.

Storage & Reheating

Allow the lasagna to cool completely before storing leftovers in an airtight container. It can be refrigerated for up to 5 days or frozen for up to 3 months. To reheat, cover with foil and bake at 350°F until heated through, about 25-30 minutes. You can also microwave individual portions for quick meals.

Nutrition & Diet Analysis (per serving)

Each serving of 25 Pound Lasagna contains roughly 1245 calories, with 30g protein, 49g carbohydrates, and 106g fat. It is an excellent source of protein (59% of the Daily Value), calcium (32% of the Daily Value), and iron (26% of the Daily Value), and a good source of vitamin C and dietary fiber. Note that it is relatively high in sodium, at 1524mg per serving (66% of the Daily Value).

1245 kcal 62% DV
Protein Fat Carbs

Macronutrients

Protein 29.6g 59% DV
Total Fat 105.5g 100% DV
Carbs 48.8g 18% DV
Fiber 4.5g 16% DV
Sugar 3.6g 7% DV

Electrolytes

Sodium 1523.5mg 66% DV
Potassium 668.1mg 14% DV
Cholesterol 76.2mg 25% DV

Vitamins & Minerals

Vitamin A 95.6mcg 11% DV
Vitamin C 16.8mg 19% DV
Vitamin D 0.2mcg 1% DV
Calcium 422.2mg 32% DV
Iron 4.6mg 26% DV
Diet fit High-protein
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this lasagna ahead of time?

Yes, you can prepare the lasagna a day in advance. Assemble it without baking, cover tightly with foil, and store in the refrigerator. When ready to serve, bake it straight from the fridge, adding an extra 10-15 minutes to the baking time to ensure it's heated through.

What can I substitute for the Mozzarella cheese?

If you prefer a different cheese, you can substitute with provolone or a blend of Italian cheeses. For a dairy-free version, try vegan cheese alternatives that melt well. Just keep in mind that the flavor and texture may vary slightly from traditional mozzarella.

How long should I bake the lasagna?

Bake the lasagna at 375°F for about 45-60 minutes, or until the cheese is bubbly and golden brown. If you used no-boil noodles, the cooking time may be slightly longer. Let it rest for 15-20 minutes before slicing, which will help the layers set and make serving easier.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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