E Z Overnite Casserole

Prep: 10 min Cook: 60 min Serves: 6 Cuisine: American

A creamy overnight casserole combining macaroni, cheese, and your choice of ham, turkey, or chicken, perfect for a comforting family meal or leftovers.

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Ingredients

  • 2 c milk
  • 1 c uncooked macaroni
  • 1 can cream of mushroom soup
  • 1 1/2 c diced ham, turkey, or chicken (cooked)
  • 1 c grated cheese

Instructions

  1. Stir all ingredients together and place in a covered 9 x 13 inch baking pan.
  2. Refrigerate overnight.
  3. Bake uncovered in a 350°F oven for 1 hour until heated through and bubbly.

Tips & Substitutions

For a creamier texture, consider adding a splash of heavy cream or sour cream to the mixture. You can also substitute the cream of mushroom soup with cream of chicken or a homemade version for a different flavor. If you prefer a vegetarian option, replace the meat with sautéed vegetables or a meat substitute. Experiment with different cheeses like cheddar or mozzarella for varied taste.

Serving Suggestions

Serve this casserole hot, garnished with fresh herbs like parsley or chives for added freshness. It pairs wonderfully with a side salad or steamed vegetables for a balanced meal. For a heartier option, consider serving it alongside crusty bread or biscuits. This dish is also great for potlucks or family gatherings, as it can easily be doubled.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, preheat your oven to 350°F and cover the casserole with foil to prevent it from drying out. Heat for about 20-30 minutes or until warmed through. You can also microwave individual portions for quicker reheating.

Nutrition & Diet Analysis (per serving)

Each serving of E Z Overnite Casserole contains roughly 380 calories, with 12g protein, 52g carbohydrates, and 14g fat. It is an excellent source of calcium (24% of the Daily Value), protein (23% of the Daily Value), and iron (20% of the Daily Value), and a good source of vitamin A. Note that it is relatively high in sodium, at 743mg per serving (32% of the Daily Value).

380 kcal 19% DV
Protein Fat Carbs

Macronutrients

Protein 11.6g 23% DV
Total Fat 14.1g 18% DV
Carbs 51.9g 19% DV
Fiber 1.3g 4% DV
Sugar 21.6g 43% DV

Electrolytes

Sodium 743.4mg 32% DV
Potassium 246.5mg 5% DV
Cholesterol 18.9mg 6% DV

Vitamins & Minerals

Vitamin A 108.9mcg 12% DV
Vitamin C 6.4mg 7% DV
Vitamin D 0.8mcg 4% DV
Calcium 306.7mg 24% DV
Iron 3.6mg 20% DV
Diet fit Under 400 cal
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I prepare the casserole without refrigeration overnight?

Absolutely! Whole wheat macaroni adds a nutty flavor and extra fiber, while gluten-free pasta can be used to accommodate dietary restrictions. Just adjust the cooking time as needed, as different pasta types may require different cooking durations.

What other meats can I use in this casserole?

You can use any leftover cooked meats such as turkey, chicken, or ham. For a unique twist, consider using pulled pork or even bacon for a smoky flavor. Just make sure the meat is already cooked, as the casserole only heats everything through.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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