Mexican Casserole(Feeds 20 Or More)

Prep: 15 min Cook: 35 min Serves: 20 Cuisine: Mexican

A hearty Mexican casserole layered with seasoned ground beef, beans, tomatoes, and cheese, perfect for feeding a large group with bold, comforting flavors.

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Ingredients

  • 3 lb. lean ground beef
  • 2 onions, chopped
  • 2 cans Ranch Style beans
  • 2 cans Ro-Tel tomatoes-green chilies
  • 2 cans cream of chicken soup
  • 1 (12) pkg. soft corn tortillas
  • 2 lb. grated cheese

Instructions

  1. Brown the ground beef and chopped onions in a skillet.
  2. Season with salt and pepper to taste.
  3. Drain off excess grease from the meat mixture.
  4. Add the Ranch Style beans, Ro-Tel tomatoes with green chilies, and cream of chicken soup to the meat mixture; stir to combine.
  5. In a large casserole dish, layer half of the corn tortillas, half of the meat mixture, and half of the grated cheese.
  6. Repeat layers with remaining tortillas, meat mixture, and cheese, ending with a cheese layer on top.
  7. Bake at 350°F (175°C) for about 35 minutes until hot and bubbly.

Tips & Substitutions

For a spicier kick, consider adding jalapeños or additional chili powder to the beef mixture. If you don't have Ranch Style beans, black or pinto beans work well as substitutes. Using corn tortillas instead of flour adds authentic texture. Remember to let the casserole rest for about 10 minutes before serving for easier slicing. Pair this dish with a side salad or guacamole for a complete meal.

Serving Suggestions

Serve this Mexican casserole with a dollop of sour cream and fresh cilantro on top for added flavor. It pairs beautifully with a side of Southwestern Chicken Salad(4 Servings) or tortilla chips for crunch. For a festive touch, add fresh avocado slices or a side of pico de gallo. This dish is great for potlucks or family gatherings.

Storage & Reheating

Store leftovers in an airtight container in the refrigerator for up to 4 days. To reheat, place individual portions in the microwave for 1-2 minutes or cover the entire casserole with foil and reheat in a 350°F oven for about 20 minutes, until heated through. This dish also freezes well for up to 2 months.

Nutrition & Diet Analysis (per serving)

Each serving of Mexican Casserole(Feeds 20 Or More) contains roughly 386 calories, with 14g protein, 40g carbohydrates, and 19g fat. It is an excellent source of protein (27% of the Daily Value), and a good source of dietary fiber and iron. Note that it is relatively high in sodium, at 725mg per serving (32% of the Daily Value).

386 kcal 19% DV
Protein Fat Carbs

Macronutrients

Protein 13.6g 27% DV
Total Fat 19.4g 25% DV
Carbs 40.2g 15% DV
Fiber 4.1g 15% DV
Sugar 3g 6% DV

Electrolytes

Sodium 725mg 32% DV
Potassium 308.8mg 7% DV
Cholesterol 34.9mg 12% DV

Vitamins & Minerals

Vitamin A 34.3mcg 4% DV
Vitamin C 0.7mg 1% DV
Vitamin D 0mcg
Calcium 84.1mg 6% DV
Iron 2.7mg 15% DV
Diet fit Under 400 cal
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I prepare the casserole in advance?

Yes, you can assemble the casserole a day ahead and store it in the refrigerator. Just make sure to cover it tightly with foil. When ready to bake, remove the foil and bake at 350°F for about 40-45 minutes, or until bubbly and heated through.

What can I use instead of cream of chicken soup?

If you're looking for a substitute, try using cream of mushroom soup or a homemade white sauce for a gluten-free option. You can also use a dairy-free cream substitute to accommodate dietary restrictions.

How can I make this dish vegetarian?

To make a vegetarian version, simply replace the ground beef with a plant-based protein such as lentils, black beans, or a meat substitute like crumbled tofu or tempeh. Ensure the cream of chicken soup is replaced with a vegetarian alternative for a complete meal.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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