Cathy'S Microwave Meatloaf

Prep: 15 min Cook: 10 min Serves: 4 Cuisine: American

A hearty microwave meatloaf bursting with savory flavors from cheese, mushrooms, and Italian seasonings, perfect for quick weeknight dinners or satisfying comfort food cravings.

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Ingredients

  • 2 lbs. ground round
  • 1 small jar Prego with mushrooms (reserve 1/2 cup)
  • 16 saltine crackers, crushed
  • 2 eggs
  • 1 small onion, finely chopped
  • 3/4 tsp. Italian seasoning
  • 1/2 tsp. garlic salt
  • 1/2 tsp. salt
  • 1/2 tsp. pepper
  • 2/3 cup shredded cheddar cheese
  • 2/3 cup shredded mozzarella cheese

Instructions

  1. In a large bowl, combine ground round, crushed saltine crackers, eggs, chopped onion, Italian seasoning, garlic salt, salt, and pepper.
  2. Add the reserved 1/2 cup of Prego with mushrooms and mix well.
  3. Spread half of the mixture into a microwave-safe loaf pan or dish.
  4. Top with 2/3 cup shredded cheddar cheese and 2/3 cup shredded mozzarella cheese.
  5. Cover with remaining meat mixture and press down gently.
  6. Microwave on high for about 8-10 minutes or until cooked through.
  7. Let stand for a few minutes before slicing and serving.

Tips & Substitutions

For a moist meatloaf, be careful not to overmix the ingredients. If you prefer a different flavor, you can substitute the Italian seasoning with a mix of dried basil and oregano. You might also try using crushed tortilla chips instead of saltines for a twist. If available, adding some chopped bell peppers can enhance the flavor profile.

Serving Suggestions

This microwave meatloaf pairs beautifully with mashed potatoes or a fresh garden salad. Consider serving it with a side of steamed vegetables for a balanced meal. You could also serve it with a generous drizzle of the reserved Prego with mushrooms for added moisture and flavor. For a fun twist, try it cold in a sandwich the next day.

Storage & Reheating

Store leftover meatloaf in an airtight container in the refrigerator for up to 3 days. To reheat, microwave individual slices for about 1-2 minutes or until heated through. You can also reheat it in the oven at 350°F (175°C) for about 15 minutes, covering it with foil to prevent drying out.

Nutrition & Diet Analysis (per serving)

Each serving of Cathy'S Microwave Meatloaf contains roughly 740 calories, with 77g protein, 19g carbohydrates, and 38g fat. It is an excellent source of protein (155% of the Daily Value), iron (37% of the Daily Value), and calcium (26% of the Daily Value), and a good source of potassium and vitamin A. Note that it is relatively high in sodium, at 2221mg per serving (97% of the Daily Value).

740 kcal 37% DV
Protein Fat Carbs

Macronutrients

Protein 77.3g 100% DV
Total Fat 37.5g 48% DV
Carbs 19.2g 7% DV
Fiber 1.5g 5% DV
Sugar 1.4g 3% DV

Electrolytes

Sodium 2221.2mg 97% DV
Potassium 689.2mg 15% DV
Cholesterol 226.9mg 76% DV

Vitamins & Minerals

Vitamin A 102mcg 11% DV
Vitamin C 20.7mg 23% DV
Vitamin D 0.3mcg 2% DV
Calcium 341.5mg 26% DV
Iron 6.7mg 37% DV
Diet fit High-protein Low-carb
Contains Milk Egg Wheat/Gluten

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this meatloaf ahead of time?

Yes, you can prepare the meatloaf mixture and shape it in advance. Cover it tightly and refrigerate for up to 24 hours before microwaving. This allows the flavors to meld together, making it even more delicious when cooked.

Can I use a different type of meat?

Absolutely! While ground round is great for this recipe, you can substitute it with ground turkey, chicken, or even a plant-based meat alternative for a vegetarian option. Just adjust cooking time accordingly, as leaner meats may cook faster.

What can I do with leftover meatloaf?

Leftover meatloaf is incredibly versatile! You can slice it for sandwiches, crumble it into a salad, or even use it as a filling for stuffed peppers. It also works well in a hearty pasta sauce or as a topping for baked potatoes.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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