Great Chicken Casserole

Prep: 20 min Cook: 45 min Serves: 6 Cuisine: American

A hearty chicken casserole combining tender chicken, creamy mushroom and chicken soups, cheesy goodness, and flavorful stuffing—perfect for comforting family dinners.

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Ingredients

  • 4 chicken breasts
  • 1 can cream of mushroom soup
  • 1 can cream of chicken soup
  • 1 small jar Cheez Whiz
  • 1/4 cup sour cream
  • 1 small onion, diced
  • 1 (4 or 8 oz.) can mushrooms
  • 1 small box Stove Top stuffing chicken flavor
  • 2 cups water

Instructions

  1. Heat oven to 350°F.
  2. Boil chicken, celery, and onion until chicken is white.
  3. In a small pot, heat the cream of mushroom soup, cream of chicken soup, Cheez Whiz, and sour cream until combined.
  4. Prepare Stove Top stuffing as directed on the package, using broth from the cooked chicken.
  5. Dice the cooked chicken.
  6. Combine the cooked chicken, mushroom mixture, and stuffing in a casserole dish.
  7. Bake in the preheated oven for about 30-45 minutes until heated through and bubbly.

Tips & Substitutions

For a twist on flavor, consider adding some sautéed garlic or a pinch of your favorite herbs to the chicken mixture. You can substitute the Cheez Whiz with shredded cheese for a different texture. If you're short on time, precooked rotisserie chicken can be an excellent shortcut. Adjust the amount of sour cream to taste for creaminess.

Serving Suggestions

This casserole is a hearty main dish that pairs well with a simple green salad or steamed vegetables for a balanced meal. Consider serving with some crusty bread to soak up the creamy sauce. For a crowd-pleasing option, it complements a Buffet Sandwich Tray perfectly.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place the casserole in the oven at 350°F until heated through, about 20 minutes. You can also microwave individual portions, but be sure to cover to retain moisture.

Nutrition & Diet Analysis (per serving)

Each serving of Great Chicken Casserole contains roughly 251 calories, with 10g protein, 31g carbohydrates, and 10g fat. It is an excellent source of vitamin D (22% of the Daily Value) and protein (20% of the Daily Value), and a good source of iron and calcium. Note that it is relatively high in sodium, at 1091mg per serving (47% of the Daily Value).

251 kcal 13% DV
Protein Fat Carbs

Macronutrients

Protein 10.1g 20% DV
Total Fat 10.1g 13% DV
Carbs 31g 11% DV
Fiber 2.1g 8% DV
Sugar 4.1g 8% DV

Electrolytes

Sodium 1091.2mg 47% DV
Potassium 478.4mg 10% DV
Cholesterol 22.1mg 7% DV

Vitamins & Minerals

Vitamin A 102.8mcg 11% DV
Vitamin C 5.6mg 6% DV
Vitamin D 4.4mcg 22% DV
Calcium 139.5mg 11% DV
Iron 1.9mg 11% DV
Diet fit Under 400 cal
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use frozen chicken for this recipe?

Yes, you can use frozen chicken breasts. Just make sure to boil them thoroughly until they reach a safe internal temperature. You may need to extend the cooking time slightly to ensure they are fully cooked before dicing.

What can I substitute for the cream of mushroom soup?

If you want to avoid canned soups, you can make a homemade version using sautéed mushrooms, butter, flour, and chicken broth. This will give you a fresher flavor and allow you to control the ingredients.

Is this casserole freezer-friendly?

Yes, this casserole can be made ahead and frozen. Assemble it without baking, cover tightly, and freeze for up to 2 months. When ready to bake, thaw overnight in the fridge, then bake as directed until heated through.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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