Hamburger Pepperoni Casserole

Prep: 15 min Cook: 35 min Serves: 4 Cuisine: American

A hearty casserole combining seasoned hamburger, rigatoni, pepperoni, and melty mozzarella for a flavorful, cheesy meal perfect for family dinner nights.

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Ingredients

  • 1 1/2 lb. hamburger
  • 1 medium onion, chopped
  • 1 large jar Ragu sauce
  • 1/2 box rigatoni noodles
  • 1 large pkg. Mozzarella cheese, sliced
  • 1 pkg. sliced pepperoni

Instructions

  1. Brown the hamburger and chopped onion in a skillet.
  2. Drain the grease from the meat mixture.
  3. Add Ragu sauce to the meat mixture and thin with water as needed.
  4. Cook rigatoni noodles according to the package instructions.
  5. In a well-greased large casserole dish, layer cooked noodles, meat mixture, sliced mozzarella cheese, and pepperoni.
  6. Repeat the layering to make two layers.
  7. Bake at 350°F (175°C) for 30 to 35 minutes until heated through and cheese is melted.

Tips & Substitutions

For added flavor, consider seasoning the hamburger with Italian herbs or garlic powder before browning. If you're looking for a lighter version, substitute ground turkey for the hamburger. You can also use whole wheat rigatoni for a healthier twist. For a kick, add some crushed red pepper flakes to the sauce. This casserole can be customized with different cheeses like cheddar or provolone.

Serving Suggestions

Serve this hearty casserole with a side salad for a balanced meal, or pair it with garlic bread for a comforting feast. A light vinaigrette salad complements the richness of the dish beautifully. For a fun twist on leftovers, consider using them in a wrap or a sandwich, reminiscent of a delicious Macaroni Caprice.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place the casserole in the oven at 350°F (175°C) for about 20 minutes or until warmed through. You can also microwave individual portions, but be sure to cover them to prevent drying out.

Nutrition & Diet Analysis (per serving)

Each serving of Hamburger Pepperoni Casserole contains roughly 350 calories, with 15g protein, 20g carbohydrates, and 23g fat. It is an excellent source of protein (30% of the Daily Value) and calcium (21% of the Daily Value). Note that it is relatively high in sodium, at 917mg per serving (40% of the Daily Value).

350 kcal 17% DV
Protein Fat Carbs

Macronutrients

Protein 14.8g 30% DV
Total Fat 23.3g 30% DV
Carbs 20.3g 7% DV
Fiber 1.2g 4% DV
Sugar 2.4g 5% DV

Electrolytes

Sodium 916.6mg 40% DV
Potassium 199.1mg 4% DV
Cholesterol 45.6mg 15% DV

Vitamins & Minerals

Vitamin A 63.5mcg 7% DV
Vitamin C 0.5mg 1% DV
Vitamin D 0.3mcg 2% DV
Calcium 269mg 21% DV
Iron 1.2mg 7% DV
Diet fit Under 400 cal
Contains Milk Wheat/Gluten

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I prepare this casserole ahead of time?

Yes, you can prepare the casserole a day in advance. Assemble it in the casserole dish, cover it tightly with foil, and refrigerate. When ready to bake, remove it from the fridge and let it sit at room temperature for about 30 minutes before baking as directed.

What can I use instead of Ragu sauce?

If you don't have Ragu sauce on hand, you can substitute it with any marinara or spaghetti sauce. Homemade sauce can also work well; just ensure it's well-seasoned for the best flavor. Alternatively, a blend of crushed tomatoes with Italian seasoning can create a delicious base.

Can I freeze Hamburger Pepperoni Casserole?

Yes, this casserole freezes well. After baking, allow it to cool completely, then wrap it tightly in plastic wrap and foil or transfer it to a freezer-safe container. It can be frozen for up to 3 months. To reheat, thaw in the refrigerator overnight and bake until warmed through.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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