Pepperoni Zucchini Casserole

Prep: 15 min Cook: 45 min Serves: 6 Cuisine: American

A cheesy, savory casserole combining zucchini, pepperoni, and mozzarella for a hearty, flavorful dish perfect for family dinners or casual gatherings.

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Ingredients

  • 4 cups zucchini, peeled, seeded and chopped
  • 1/2 cup chopped onion
  • 2 cups shredded Mozzarella cheese
  • 2 tablespoons grated Parmesan cheese
  • 1/2 to 1 cup chopped pepperoni
  • salt to taste
  • pepper to taste
  • basil to taste
  • oregano to taste

Instructions

  1. Preheat oven to 350°F.
  2. Spray a 9 x 13-inch baking dish with cooking spray and set aside.
  3. In a large bowl, combine peeled, seeded, and chopped zucchini, chopped onion, shredded mozzarella, grated Parmesan, pepperoni, salt, pepper, basil, and oregano.
  4. Mix thoroughly and set aside.
  5. In another bowl, combine oil, eggs, and Bisquick and mix well.
  6. Add the wet mixture to the zucchini mixture and blend thoroughly.
  7. Pour the batter into the prepared baking dish.
  8. Bake in the preheated oven for approximately 45 minutes or until golden and cooked through.

Tips & Substitutions

For a lighter version, consider using turkey pepperoni instead of regular. You can also add other vegetables like bell peppers or mushrooms for extra flavor and nutrition. If you're short on time, pre-shredded cheese works well, but fresh cheese will melt better. Make sure to drain any excess moisture from the zucchini to avoid a soggy casserole.

Serving Suggestions

This casserole is perfect as a main dish, but it can be paired with a simple green salad or garlic bread for a complete meal. Consider serving it alongside Grandma'S Low-Fat Casserole for a comforting dinner spread. Leftovers can also be enjoyed for lunch the next day, making it a versatile option.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to three days. To reheat, place individual portions in the microwave for 1-2 minutes, or reheat in the oven at 350°F for about 15 minutes until warmed through. This casserole can also be frozen for up to three months; just thaw before reheating.

Nutrition & Diet Analysis (per serving)

Each serving of Pepperoni Zucchini Casserole contains roughly 1470 calories, with 5g protein, 5g carbohydrates, and 162g fat. It is a good source of protein (10% of the Daily Value). Note that it is relatively high in sodium, at 1311mg per serving (57% of the Daily Value).

1470 kcal 74% DV
Protein Fat Carbs

Macronutrients

Protein 4.8g 10% DV
Total Fat 162g 100% DV
Carbs 4.6g 2% DV
Fiber 0g
Sugar 0.3g 1% DV

Electrolytes

Sodium 1310.6mg 57% DV
Potassium 69.6mg 1% DV
Cholesterol 7.8mg 3% DV

Vitamins & Minerals

Vitamin A 15.3mcg 2% DV
Vitamin C 0.2mg
Vitamin D 0mcg
Calcium 104.7mg 8% DV
Iron 0.5mg 3% DV
Diet fit Keto-friendly
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use other types of cheese in this recipe?

Yes, you can substitute other cheeses like cheddar or provolone for a different flavor profile. Just keep in mind that the texture and taste may vary slightly, so choose a cheese that melts well.

Is it necessary to peel the zucchini?

Peeling the zucchini is not mandatory, but it helps to reduce the bitterness and moisture content. If you prefer a more rustic texture, feel free to leave the skin on.

Can I prepare this casserole ahead of time?

Absolutely! You can assemble the casserole a day in advance and store it in the fridge. Just bake it when you're ready to serve. This makes it a great option for busy weeknights or gatherings.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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