Six-Layer Mexican Casserole

Prep: 20 min Cook: 40 min Serves: 8 Cuisine: Mexican

A hearty and flavorful six-layer Mexican casserole featuring seasoned ground beef, beans, cheese, and tortillas. Perfect for family dinners or gatherings, its rich layers and bold flavors make it a satisfying comfort food that combines classic Mexican ingredients in a convenient baked dish.

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Ingredients

  • 12 corn tortillas
  • 1 lb. grated Cheddar cheese
  • 1 can cream of chicken soup
  • 1 can tomatoes and green chilies
  • 2 lb. ground beef
  • 1 Tbsp. chili powder
  • 1 onion, chopped fine
  • 2 cans Ranch Style beans

Instructions

  1. Place 6 uncooked tortillas on the bottom of a 9 x 13-inch pan.
  2. Cook and crumble 2 pounds of ground beef with 1 chopped onion and 1 tablespoon chili powder until browned.
  3. Spread a layer of cooked ground beef over the tortillas.
  4. Spoon a can of cream of chicken soup evenly over the beef layer.
  5. Sprinkle a can of tomatoes and green chilies over the soup.
  6. Add a layer of Ranch Style beans over the chili mixture.
  7. Sprinkle 1 pound of grated Cheddar cheese over the beans.
  8. Repeat the layers with remaining tortillas, beef, soup, chilies, beans, and cheese.
  9. Bake in a preheated oven at 350°F (175°C) for about 40 minutes until hot and bubbly.
  10. Let stand for a few minutes before slicing and serving.

Tips & Substitutions

For a spicier kick, consider adding jalapeños or using spicy cheese. You can substitute ground turkey or chicken for the beef if you prefer a leaner option. If you're short on time, use pre-cooked shredded chicken from recipes like Southwestern Chicken 'N Shells. Additionally, corn tortillas can be replaced with flour tortillas for a different texture.

Serving Suggestions

This casserole is hearty on its own but pairs well with a fresh green salad or a dollop of sour cream on top. For a complete meal, serve alongside Mexican rice or refried beans. It also complements well with recipes like West Texas Tortilla Soup for a delicious Mexican-themed dinner.

Storage & Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, cover the casserole with foil and warm it in a preheated oven at 350°F (175°C) for about 20 minutes. Alternatively, individual portions can be microwaved until heated through.

Nutrition & Diet Analysis (per serving)

Each serving of Six-Layer Mexican Casserole contains roughly 938 calories, with 29g protein, 102g carbohydrates, and 48g fat. It is an excellent source of protein (59% of the Daily Value), dietary fiber (43% of the Daily Value), and vitamin A (43% of the Daily Value), and a good source of potassium. Note that it is relatively high in sodium, at 2106mg per serving (92% of the Daily Value).

938 kcal 47% DV
Protein Fat Carbs

Macronutrients

Protein 29.3g 59% DV
Total Fat 48.3g 62% DV
Carbs 102.2g 37% DV
Fiber 12g 43% DV
Sugar 10.1g 20% DV

Electrolytes

Sodium 2105.6mg 92% DV
Potassium 739.8mg 16% DV
Cholesterol 71.3mg 24% DV

Vitamins & Minerals

Vitamin A 389mcg 43% DV
Vitamin C 17.7mg 20% DV
Vitamin D 0.3mcg 2% DV
Calcium 526.1mg 40% DV
Iron 6.2mg 34% DV
Diet fit High-protein High-fiber
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can assemble the casserole a day in advance. Cover it tightly with plastic wrap and refrigerate. Just add a few extra minutes to the baking time when you're ready to cook it.

Can I freeze this casserole?

Absolutely! You can freeze the assembled casserole before baking. Wrap it tightly with plastic wrap and then foil. It can be frozen for up to 3 months. When ready to bake, thaw overnight in the refrigerator before cooking as directed.

What can I use instead of cream of chicken soup?

If you're looking for a substitute, you can use homemade cream of chicken soup, or swap it for a can of cream of mushroom soup for a different flavor. For a lighter option, opt for a creamy white sauce made with milk and flour.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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