Stuffed Pizza Casserole
A cheesy, savory stuffed pizza casserole combining ground beef, sausage, and mozzarella, with a biscuit crust—perfect for family dinners and pizza lovers alike.
Ingredients
Instructions
- Preheat oven to 450°F.
- Brown sausage and ground beef in a skillet until crumbly; drain and set aside.
- Mix Bisquick and cold water until dough forms.
- Divide the dough into two parts, with one slightly larger than the other.
- Press the larger piece of dough into the bottom of a greased 9 x 13-inch baking dish, pressing the dough up the sides of the dish.
- Spread spaghetti sauce over the dough in the baking dish.
- Sprinkle shredded mozzarella cheese over the sauce.
- Add your favorite pizza toppings on top of the cheese.
- Place the second piece of dough over the toppings and press down gently.
- Bake in the preheated oven for approximately 25 minutes until golden and bubbly.
Tips & Substitutions
For a richer flavor, consider adding spices like Italian seasoning or garlic powder to the beef and sausage mixture. If you're out of Bisquick, you can substitute an equal amount of all-purpose flour mixed with baking powder and salt. Feel free to get creative with your toppings; pepperoni, mushrooms, and bell peppers work well in this dish. For a veggie option, consider using the toppings from Vegetable-Beef Chili.
Serving Suggestions
Serve the stuffed pizza casserole hot out of the oven with a side salad or garlic bread for a complete meal. It pairs beautifully with Easy Cheesy Meat Loaf for a hearty dinner. You can also drizzle a bit of extra spaghetti sauce on top before serving for added flavor. This dish is perfect for game days or family gatherings.
Storage & Reheating
Leftover stuffed pizza casserole can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, place individual portions in the microwave for about 1-2 minutes or until heated through. You can also reheat the casserole in the oven at 350°F for about 15-20 minutes for a crispier texture.
Nutrition & Diet Analysis (per serving)
Each serving of Stuffed Pizza Casserole contains roughly 329 calories, with 19g protein, 28g carbohydrates, and 16g fat. It is an excellent source of protein (38% of the Daily Value) and calcium (23% of the Daily Value), and a good source of dietary fiber and iron. Note that it is relatively high in sodium, at 497mg per serving (22% of the Daily Value).
Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.
* % Daily Values based on a 2,000 calorie diet (FDA 2020).
Frequently Asked Questions
Can I make this casserole ahead of time?
Yes, you can prepare the casserole and refrigerate it before baking. Just be sure to cover it tightly with plastic wrap or foil. When you're ready to bake, remove the cover and bake it at 450°F for about 30-35 minutes, or until heated through and golden brown.
What are some good topping combinations?
Popular topping combinations include classic pepperoni and mushrooms, or a meat lover's mix with sausage, bacon, and ham. For a delicious veggie option, try bell peppers, olives, and spinach. You can also use leftovers from California Beef And Rice Skillet for a unique twist.
Can I freeze the stuffed pizza casserole?
Absolutely! You can freeze the casserole before baking. Wrap it tightly in plastic wrap and then aluminum foil to prevent freezer burn. When you're ready to enjoy it, thaw it in the refrigerator overnight and bake as directed. It can also be frozen after baking, but the texture may change slightly.
Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).