Zesty Beef-Biscuit Casserole

Prep: 10 min Cook: 20 min Serves: 4 Cuisine: American

A flavorful casserole combining seasoned ground beef, cheesy biscuits, and creamy sour cream, perfect for satisfying family dinners with bold, comforting tastes.

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Ingredients

  • 1 1/4 lb. ground beef
  • 1/2 c. chopped onion
  • 1/4 c. diced green pepper
  • 1 (8 oz.) can tomato sauce
  • 2 tsp. chili powder
  • 1/2 tsp. garlic salt
  • 1 tube refrigerated biscuits
  • 1 1/2 c. shredded Cheddar cheese
  • 1/2 c. sour cream

Instructions

  1. Crumble ground beef into a skillet.
  2. Add chopped onion and diced green pepper to the skillet.
  3. Cook on medium heat until the meat loses its red color.
  4. Drain off excess fat from the skillet.
  5. Stir in tomato sauce, chili powder, and garlic salt.
  6. Simmer the mixture while preparing the dough.

Tips & Substitutions

For added depth of flavor, consider browning the ground beef with a tablespoon of Worcestershire sauce. If you prefer a spicier kick, add diced jalapeños or a dash of hot sauce to the beef mixture. You can also substitute ground turkey or chicken for a lighter option. If you’re out of tomato sauce, crushed tomatoes or salsa work well as a substitute.

Serving Suggestions

Serve the Zesty Beef-Biscuit Casserole with a fresh green salad or roasted vegetables for a complete meal. It pairs beautifully with cornbread or garlic bread. For a fun twist, top with sliced avocados or a dollop of guacamole. This dish is also great for potlucks, offering a hearty option among other American recipes.

Storage & Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place in a microwave-safe dish and cover with a damp paper towel to maintain moisture. Heat in 30-second intervals until warmed through, or reheat in a preheated oven at 350°F until hot, approximately 15-20 minutes.

Nutrition & Diet Analysis (per serving)

Each serving of Zesty Beef-Biscuit Casserole contains roughly 371 calories, with 15g protein, 60g carbohydrates, and 10g fat. It is an excellent source of vitamin C (83% of the Daily Value), vitamin A (42% of the Daily Value), and protein (29% of the Daily Value). Note that it is relatively high in sodium, at 755mg per serving (33% of the Daily Value).

371 kcal 19% DV
Protein Fat Carbs

Macronutrients

Protein 14.5g 29% DV
Total Fat 10.2g 13% DV
Carbs 60.5g 22% DV
Fiber 7.2g 26% DV
Sugar 4.9g 10% DV

Electrolytes

Sodium 755.4mg 33% DV
Potassium 954.1mg 20% DV
Cholesterol 110.4mg 37% DV

Vitamins & Minerals

Vitamin A 377.1mcg 42% DV
Vitamin C 74.7mg 83% DV
Vitamin D 0mcg
Calcium 330.7mg 25% DV
Iron 4.3mg 24% DV
Diet fit High-fiber Under 400 cal Low-fat
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes, you can prepare the beef mixture and assemble the casserole ahead of time. Cover and refrigerate it for up to 24 hours. When ready to bake, let it sit at room temperature for about 30 minutes before placing it in the oven to ensure even cooking.

What can I use instead of biscuits?

If you want to try a different base, you can use crescent roll dough or even homemade biscuit dough. For a gluten-free option, consider using gluten-free biscuit mix. Just ensure the cooking times are adjusted according to the dough you choose.

Can I freeze the casserole?

Yes, this casserole freezes well. To freeze, cool it completely and transfer it to a freezer-safe container. It can be stored for up to 3 months. To reheat, thaw in the refrigerator overnight and bake at 350°F until heated through.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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