Chicken Cleopatra

Prep: 15 min Cook: 30 min Serves: 4 Cuisine: Mediterranean

Juicy chicken breasts simmered with mushrooms, artichokes, and Marsala wine create a rich, flavorful dish perfect for elegant dinners or special occasions.

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Ingredients

  • 4 boneless chicken breasts
  • 1 lb. mushrooms, sliced
  • 1 whole white onion, chopped
  • 1 can artichoke hearts, sliced
  • 3 Tbsp. olive oil
  • 1/2 c. Marsala wine
  • flour
  • granulated garlic
  • salt
  • pepper

Instructions

  1. Season the chicken breasts with granulated garlic, salt, and pepper, then dredge them in flour.
  2. Heat 3 tablespoons of olive oil in a large skillet over medium heat.
  3. Add the chicken breasts and cook until browned on both sides, about 5-7 minutes per side. Remove and set aside.
  4. In the same skillet, add the chopped onion and sliced mushrooms. Cook until the onion is translucent and mushrooms are browned.
  5. Add the sliced artichoke hearts to the skillet and cook for another 2-3 minutes.
  6. Pour in the Marsala wine to deglaze the pan, scraping up any browned bits from the bottom.
  7. Add the chicken stock to the skillet and bring to a simmer.
  8. Return the chicken breasts to the skillet, cover, and cook for an additional 15-20 minutes until the chicken is cooked through and flavors melded.

Tips & Substitutions

For extra flavor, marinate the chicken in olive oil, garlic, and herbs for an hour before cooking. If you need a gluten-free option, use cornstarch instead of flour for dredging. You can also substitute the Marsala wine with white wine or chicken broth if needed. Consider adding some fresh herbs like thyme or rosemary for an aromatic touch.

Serving Suggestions

Serve Chicken Cleopatra over a bed of rice or pasta to soak up the flavorful sauce. A side of steamed vegetables or a fresh salad pairs nicely. For a Mediterranean twist, consider serving it alongside some crusty bread or pairing it with a glass of white wine. This dish is also an excellent companion to Chicken With Artichokes And Peas.

Storage & Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, warm in a skillet over medium heat until heated through, adding a splash of chicken stock if it seems dry. Alternatively, you can reheat in the microwave, covered, in short intervals to prevent overcooking.

Nutrition & Diet Analysis (per serving)

Each serving of Chicken Cleopatra contains roughly 305 calories, with 27g protein, 24g carbohydrates, and 11g fat. It is an excellent source of vitamin D (133% of the Daily Value) and protein (55% of the Daily Value), and a good source of iron and potassium. Note that it is relatively high in sodium, at 782mg per serving (34% of the Daily Value).

305 kcal 15% DV
Protein Fat Carbs

Macronutrients

Protein 27.3g 55% DV
Total Fat 11.5g 15% DV
Carbs 24.2g 9% DV
Fiber 3.9g 14% DV
Sugar 7g 14% DV

Electrolytes

Sodium 781.9mg 34% DV
Potassium 766.7mg 16% DV
Cholesterol 64.6mg 22% DV

Vitamins & Minerals

Vitamin A 24.2mcg 3% DV
Vitamin C 12.5mg 14% DV
Vitamin D 26.6mcg 100% DV
Calcium 58.1mg 4% DV
Iron 2.9mg 16% DV
Diet fit High-protein Under 400 cal
Contains Wheat/Gluten

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use other types of wine besides Marsala?

Yes, you can substitute Marsala with other wines like white wine or even a dry sherry. Just keep in mind that the flavor profile will change slightly, but it will still provide a delicious sauce for the dish.

Is it possible to make this dish ahead of time?

Absolutely! You can prepare the dish up to the point of adding the chicken back to the skillet. Store the cooked mixture separately, then combine and heat when you're ready to serve. This makes for a convenient weeknight dinner or meal prep.

What can I do if I don't have artichoke hearts?

If you don't have artichoke hearts on hand, you can substitute them with green olives or roasted red peppers for a different flavor profile. Alternatively, you can omit them entirely and still enjoy a delicious chicken dish.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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