My Buddy'S Pizza Casserole

Prep: 15 min Cook: 15 min Serves: 6 Cuisine: American

A hearty, cheesy casserole combining seasoned ground beef, colorful vegetables, spicy pepperoni, and pasta, perfect for family dinners and comfort food lovers.

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Ingredients

  • 1 lb ground beef
  • 1 medium onion, chopped
  • 1 medium green pepper, chopped
  • 1/2 lb sliced pepperoni
  • 1 large can mushrooms
  • 1 large jar spaghetti sauce
  • 1 cup elbow macaroni
  • 1 cup shell macaroni
  • 1 cup spiral macaroni
  • 2 cups grated Mozzarella cheese

Instructions

  1. In a large skillet, brown the ground beef, chopped onion, chopped green pepper, sliced pepperoni, and mushrooms.
  2. Drain excess grease from the skillet.
  3. Add spaghetti sauce to the meat mixture and stir.
  4. Cook elbow, shell, and spiral macaroni in boiling water until soft; drain.
  5. Combine the cooked noodles with the meat sauce in a large casserole dish.
  6. Sprinkle grated Mozzarella cheese over the top.
  7. Bake at 350°F (175°C) for 15 minutes until cheese is melted and bubbly.

Tips & Substitutions

For a twist, consider adding Italian sausage for extra flavor or substituting whole wheat pasta for a healthier option. You can also use any leftover vegetables you have on hand, such as zucchini or spinach, to boost nutrition. If you prefer a spicier dish, add crushed red pepper flakes to the meat mixture. This casserole can easily be customized to your taste, just like in other American recipes.

Serving Suggestions

This pizza casserole is a hearty dish that pairs well with a fresh side salad or Wonderful Cole Slaw for added crunch. You can also serve it with garlic bread to soak up the delicious sauce. For a complete meal, consider serving with a light dessert, like fruit salad, to balance the richness of the casserole.

Storage & Reheating

To store leftovers, allow the casserole to cool completely before transferring it to an airtight container. It can be refrigerated for up to 3-4 days. When reheating, cover it with foil to prevent the cheese from burning and warm it in a preheated oven at 350°F (175°C) until heated through, about 20-25 minutes.

Nutrition & Diet Analysis (per serving)

Each serving of My Buddy'S Pizza Casserole contains roughly 371 calories, with 17g protein, 20g carbohydrates, and 25g fat. It is an excellent source of vitamin C (37% of the Daily Value), protein (33% of the Daily Value), and vitamin D (23% of the Daily Value), and a good source of calcium and iron. Note that it is relatively high in sodium, at 696mg per serving (30% of the Daily Value).

371 kcal 19% DV
Protein Fat Carbs

Macronutrients

Protein 16.7g 33% DV
Total Fat 25.1g 32% DV
Carbs 19.9g 7% DV
Fiber 1.9g 7% DV
Sugar 4.1g 8% DV

Electrolytes

Sodium 696.5mg 30% DV
Potassium 361.6mg 8% DV
Cholesterol 54.4mg 18% DV

Vitamins & Minerals

Vitamin A 52mcg 6% DV
Vitamin C 33.1mg 37% DV
Vitamin D 4.6mcg 23% DV
Calcium 188.2mg 14% DV
Iron 1.7mg 10% DV
Diet fit Low-carb Under 400 cal
Contains Milk

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I make this casserole ahead of time?

Yes! You can prepare the casserole up to the baking step, cover it tightly with plastic wrap, and refrigerate it for up to 24 hours. When ready to bake, remove it from the fridge and let it sit at room temperature for about 30 minutes before placing it in the oven to ensure even cooking.

Can I freeze the pizza casserole?

Absolutely! This casserole freezes well. Assemble the dish, cover it tightly with foil, and freeze for up to 3 months. To bake, thaw it overnight in the refrigerator before cooking, or bake it straight from the freezer at a lower temperature, extending the cooking time by about 15-20 minutes.

What can I substitute for the ground beef?

You can substitute ground turkey or chicken for a leaner option, or use plant-based ground meat for a vegetarian version. Additionally, crumbled Italian sausage can add a delicious flavor twist, making it a versatile recipe that accommodates different dietary preferences.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

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