Tuna And Cheese Biscuit Casserole

Prep: 15 min Cook: 30 min Serves: 6 Cuisine: American

A savory casserole combining tuna, cheese, and biscuits with creamy mushroom flavor, perfect for a comforting family meal or casual gathering.

Be the first to rate this recipe

Ingredients

  • 1 (9 1/4 oz.) can tuna, drained
  • 1/4 tsp. celery seed
  • 1 small minced onion
  • 2 Tbsp. margarine
  • 2 Tbsp. flour
  • 1/2 cup milk
  • 1 can cream of mushroom soup
  • Bisquick
  • 1 (5 oz.) jar Smokey or Old English cheese spread

Instructions

  1. Brown the minced onion in margarine.
  2. Add celery seed and cook briefly.
  3. Stir in flour and mix well.
  4. Gradually add milk, stirring constantly until smooth.
  5. Stir in cream of mushroom soup and drained tuna.
  6. Pour the mixture into a buttered 1 1/2-quart casserole dish.
  7. Prepare biscuit dough according to Bisquick directions.
  8. Spread the cheese spread over the biscuit dough and roll out.
  9. Slice the rolled dough into 1 1/4-inch thick pieces.
  10. Arrange the sliced dough on top of the tuna mixture in the casserole.
  11. Bake at 400°F for 30 minutes or until biscuits are cooked underneath.
  12. If biscuits are too brown, reduce the oven temperature.

Tips & Substitutions

For a creamier texture, consider adding a splash of sour cream or Greek yogurt to the tuna mixture. If you prefer a different flavor, substitute the cream of mushroom soup with cream of celery or chicken. Fresh herbs like dill or parsley can enhance the dish significantly. For a lighter version, use low-fat cheese spread and margarine.

Serving Suggestions

This casserole pairs beautifully with a fresh green salad or steamed vegetables for a complete meal. For a heartier option, serve with crusty bread or garlic knots. Consider a side of pickles or olives to add a briny contrast to the richness of the dish. It’s also great for potlucks or family gatherings.

Storage & Reheating

Store any leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place in the oven at 350°F for about 15-20 minutes or until warmed through. You can also microwave individual portions, but be sure to cover them to retain moisture.

Nutrition & Diet Analysis (per serving)

Each serving of Tuna And Cheese Biscuit Casserole contains roughly 381 calories, with 12g protein, 71g carbohydrates, and 5g fat. It is an excellent source of iron (27% of the Daily Value) and protein (24% of the Daily Value).

381 kcal 19% DV
Protein Fat Carbs

Macronutrients

Protein 12.1g 24% DV
Total Fat 5g 6% DV
Carbs 70.6g 26% DV
Fiber 2.3g 8% DV
Sugar 11.9g 24% DV

Electrolytes

Sodium 208.2mg 9% DV
Potassium 226.3mg 5% DV
Cholesterol 7.5mg 2% DV

Vitamins & Minerals

Vitamin A 52.8mcg 6% DV
Vitamin C 5mg 6% DV
Vitamin D 0.6mcg 3% DV
Calcium 120.6mg 9% DV
Iron 4.9mg 27% DV
Diet fit Under 400 cal Low-fat
Contains Milk Wheat/Gluten Fish

Estimated from ingredients & per-serving nutrition — verify against package labels for allergies or strict diets.

* % Daily Values based on a 2,000 calorie diet (FDA 2020).

Frequently Asked Questions

Can I use fresh tuna instead of canned tuna?

Yes, you can use fresh tuna. Just make sure to cook it fully before adding it to the casserole. Fresh tuna will give a different texture and flavor, so adjust seasonings accordingly.

How can I make this dish gluten-free?

To make this casserole gluten-free, use a gluten-free biscuit mix instead of Bisquick and ensure that your cream of mushroom soup is free of gluten. Many brands offer gluten-free alternatives that work well in this recipe.

Can I make this ahead of time?

Absolutely! You can prepare the tuna mixture and biscuit dough a day ahead. Assemble the casserole and refrigerate it, then bake it when you're ready to serve. Just add a few extra minutes to the baking time if it's going in cold.

Nutrition is estimated from USDA FoodData Central ingredient data and may vary with brand, portion and preparation — see our methodology. This information is for general educational purposes only and is not medical or dietary advice (disclaimer).

American recipes → Seafood recipes → Dairy recipes → All recipes →